Andrew E. M. Davis

This paper introduces a measure of transcriptional dyscoordination to quantify aging in single cells, showing it increases with age and is linked to cellular processes like senescence and genome instability.

The paper introduces an EpiTag zebrafish transgenic reporter to visualize epigenetic silencing/activation and identifies tissue-specific epigenetic regulatory genes through mutagenesis screening.

This paper characterizes the zebrafish meninges using single-cell transcriptomics, identifying a novel cell type essential for brain development.

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

The paper introduces a zebrafish transgenic line to profile endothelial cell translatomes in vivo, revealing novel genes and expression signatures across adult organs.

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

SenPred uses scRNA-seq to classify senescent cells and detects in vivo senescent cell burden with high accuracy.

This paper demonstrates the use of CRISPR-Cas9 dgRNPs to generate pigment-free, immobile zebrafish embryos and larvae across genetic backgrounds, enhancing live imaging capabilities.

This study investigates the in vivo roles of RHOA in vascular development and integrity using zebrafish models, finding that both gain- and loss-of-function lead to vascular dysfunction.

This study identifies miR-204 as a key regulator of lymphangiogenesis, showing its role in lymphatic vessel formation and its interaction with NFATC1.