Maria R. Narciso

This study shows that Rab7 activation improves lysosomal dynamics and mitophagic flux in iron overload, enhancing mitochondrial function and cell survival.

This study shows that lysosome pH is critical for LPS-induced lysosome tubulation in macrophages, as alkalinizing pH blocks tubulation while maintaining mTORC1 activity.

The paper shows PIKfyve regulates ER dynamics by balancing phosphoinositides at ER-lysosome contacts, affecting lysosome fission and ER morphology.