Author

Shiraz Anwar

Toronto Metropolitan UniversityORCID 0009-0007-2980-6517Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Maria R. NarcisoiD· 2 shared Roberto J. BotelhoiD· 2 shared Eddie Tam· 1 shared Gary SweeneyiD· 1 shared Hye Kyoung Sung· 1 shared Melanie MansatiD· 1 shared Mojca Mattiazzi UšajiD· 1 shared Nazia Chowdhury· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCell Biology

Maria R. NarcisoORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintNov 12, 2026

Rab7 activation ameliorates impaired lysosome dynamics and mitophagic flux during chronic iron overload

Melanie Mansat, Hye Kyoung Sung, Eddie Tam…·Roberto J. Botelho

This study shows that Rab7 activation improves lysosomal dynamics and mitophagic flux in iron overload, enhancing mitochondrial function and cell survival.

DOI 10.64898/2026.11.10.765721

experimental assaycell signaling & trafficking

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Cell BiologyMolecular Biology of the CellPeer-reviewedOct 8, 2026

Dissipation of lysosome pH impairs formation and collapses existing LPS-induced lysosome tubules in macrophages

Shiraz Anwar, Solmaz Ebrahimi-Iranpour, Maria R. Narciso…·Roberto J. Botelho

This study shows that lysosome pH is critical for LPS-induced lysosome tubulation in macrophages, as alkalinizing pH blocks tubulation while maintaining mTORC1 activity.

DOI 10.1091/mbc.e25-09-0457

mouseproteomics

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