Steven V John

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.

This study identifies the pyruvate branch point as a metabolic checkpoint controlling lymphoid cancer cell migration and dissemination via mROS/HIF-1a signaling.

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.