Jing Fan

This study uses multi-omic analysis to show NO* drives controlled remodeling in macrophages, with AKR1A1 mediating negative regulation of metabolic and functional changes during immune response.

The paper identifies sulfur-containing metabolites specific to inflammatory macrophages, showing they are produced from cysteine and central metabolism intermediates and are elevated in human inflammatory lesions.

This study identifies the pyruvate branch point as a metabolic checkpoint controlling lymphoid cancer cell migration and dissemination via mROS/HIF-1a signaling.

This study shows that acetyl-CoA availability, regulated by AT-1, affects neuronal metabolism, growth, and synaptic activity in mice.

Autofluorescence imaging informs manufacturing conditions that enhance yield and metabolic fitness of CAR T cells for neuroblastoma.

This study uses optical metabolic imaging to show neutrophils rapidly shift to a reduced redox state upon activation, with heterogeneous responses across cells and donors.

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

This study shows that mature neutrophils can rapidly reactivate mitochondrial metabolism in response to stimuli, impacting their function and suggesting therapeutic potential for mitochondrial pyruvate carrier inhibitors.

This study shows that heme biosynthesis regulates BCAA catabolism and thermogenesis in brown adipose tissue by affecting UCP1 and mitochondrial function.

This study shows that GATA1-deficient iPSC-derived neutrophils have enhanced antifungal activity against Aspergillus fumigatus, mediated by CD18 integrin.

This paper introduces a microfluidics-based thrombus profiling assay that detects intensified biomechanical thrombogenesis in hypertension and aging, revealing a GPIb-integrin mechanosensing axis hyperactivity mechanism.

The paper introduces a method using the Orbitrap Astral mass spectrometer with DIA to rapidly analyze phosphoproteomes, detecting over 80,000 phosphorylation sites in mice.