Juan Carlos de la Torre

This study evaluates a bivalent Lassa virus mRNA vaccine in mice and guinea pigs, showing it provides complete protection against lethal infection, whereas monovalent vaccines do not.

This study identifies Sirt-1 as a host factor required for optimal LCMV multiplication and suggests repurposing Sirt-1 inhibitors as antivirals.

This study identifies sphingolipid metabolism as a target for antiviral strategies against mammarenaviruses by showing that inhibiting nSMase2 reduces viral production.

This paper shows halofuginone inhibits mammarenavirus replication by targeting prolyl-tRNA synthetase, leading to translation inhibition and reduced viral budding.

The paper screens a compound library to identify anti-mammarenavirus agents, finding CRM1/XPO1 inhibitors as promising therapeutic targets.

This study shows NMT inhibitors remain effective against viruses like HSV-1 even when JAK inhibitors like ruxolitinib are present, suggesting their use in treating immunosuppression-related viral infections.

The paper investigates the role of Z protein myristoylation and oligomerization in inhibiting vRNP activity, finding that inhibition is dose-dependent and monomeric-dependent, not requiring myristoylation.

This study shows that NMT inhibition reduces mammarenavirus replication by impairing Z protein budding and GP2 fusion activity.

This study shows that PKR activation can both restrict and enhance LCMV replication, revealing a complex role for PKR in mammarenavirus infection.

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.

This study shows SARS-CoV-2 can infect brain cells and organoids derived from human induced pluripotent stem cells, leading to cell death and inflammation, and suggests using these models to study the virus's effects on the brain.