Elise Landais

Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.