Gabriel Ozorowski

This study shows that mRNA vaccines can prime and mature ultrarare HIV bnAb precursor B cells in NHPs, with improved affinity using a modified immunogen.

This study shows that sequential vaccination can mature VRC01-class B cells into antibodies that neutralize a broad range of HIV-1 viruses.

This study tracks germinal center responses in rhesus macaques over a year, showing prolonged GCs with declining SHM and ongoing plasma cell production.

This paper describes the development and cGMP manufacturing of an HIV vaccine candidate for clinical trials, demonstrating scalable production and quality control.

Across 119 monoclonal germinal centers, B cell affinity rises reliably despite divergent phylogenies. Selection is noisy but persistent; mutability limits exploration. A DMS-based landscape shows saturating fitness and survivorship biases.

This study shows that a germline-targeting HIV immunogen induces cross-neutralizing antibodies in outbred macaques by priming V2-apex bnAb B cell precursors.

This study uses cryoEM and machine learning to predict and redirect immunodominant epitopes in HIV Env, showing improved vaccine antigen design.

The paper designs native-like HIV Env single-chain trimers (SCTs) that are stable, immunogenic, and compatible with vaccine delivery methods.

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

This study shows that HIV Env trimers coupled to liposomes induce cross-neutralizing antibodies in NHPs that mimic human bNAbs targeting the Env trimer apex.

This study shows that targeting the conserved HIV fusion peptide with modified Env immunogens in rhesus macaques can focus immune responses on neutralizing epitopes.

This paper uses cryoEM to analyze antibody-antigen interactions with HIV MPER-GT immunogens, revealing binding patterns and epitopes that inform antigen optimization.

Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.

This study shows that combining slow antigen delivery and follicle-targeting adjuvants enhances germinal center B cell diversity and clonal expansion in mice.

This study compares bnAb precursor responses in infant and juvenile rhesus macaques after germline-targeting HIV Env immunization, finding higher rates in infants.

The paper presents a nanodisc platform for assembling transmembrane glycoproteins into vaccine candidates, demonstrating its utility in HIV vaccine development through structural and functional analyses.

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

This study shows that a multi-dose immunization with germline-targeting SOSIP vaccines induces precursor broadly neutralizing antibodies in infant macaques, similar to adult responses.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.