Devin Sok

This paper demonstrates the feasibility of expressing monoclonal IgG and IgA antibodies in non-human primates using mRNA-LNPs, showing both isotypes retain HIV-neutralizing function and native-like glycosylation.

The paper isolates antibodies from a Shigella outbreak in non-human primates, showing some target O-antigen and T3SS proteins, with some antibodies enhancing virulence.

This study improves HIV broadly neutralizing antibodies through multistate engineering, resulting in enhanced breadth and potency against diverse Env variants.

This paper improves the affinity and potency of a monoclonal antibody against Shigella flexneri 3a O-antigen using phage display and whole-cell panning, showing enhanced antibacterial activity and broader serotype recognition.

Membrane-bound BG505 MD39.3 Env trimer delivered as mRNA-LNP reduced base-directed antibody responses in rabbits and macaques and elicited neutralizing antibodies, with memory B cell responses documented in macaques.

This study compares neutralization profiles of contemporary HIV-1 clade C viruses from India and South Africa against broadly neutralizing antibodies, finding distinct resistance patterns and env signatures.

The paper presents a nanodisc platform for assembling transmembrane glycoproteins into vaccine candidates, demonstrating its utility in HIV vaccine development through structural and functional analyses.

This study immunized cows with HIV Env trimers to generate broadly neutralizing antibodies targeting the V2-apex, revealing ultralong CDRH3 antibodies outcompete shorter ones in the response.

This study investigates whether engineering HIV Env trimers or using gp120 can induce broadly neutralizing antibodies in cows, finding that trimers are more effective than monomeric gp120.

The paper analyzes B cell responses to a germline-targeting immunogen in human Ig loci transgenic mice, finding diverse non-VRC01-class B cells and competitor B cells recognizing epitopes near the VRC01 epitope.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

The paper develops a single-cell barcoding method to capture immune receptor sequences from tumor-infiltrating lymphocytes without sorting or culturing, demonstrating its application on ovarian cancer samples.