Georg Ramm

This paper introduces curved and corrugated cryo-lamella designs to improve mechanical resilience and reduce lamella loss during electron microscopy sample preparation.

This study profiles bioenergetic changes in fresh human kidney tissue from diabetic patients with preserved function, revealing compensatory metabolic adaptation and intrinsic mitochondrial dysfunction.

This paper introduces two modifications to cryo-lamella preparation to reduce crack formation and improve mechanical resistance during imaging.

The paper introduces a modification to cryo-FIB milling patterns by adding fillets to reduce stress concentration and lamella breakage, improving yield by 33%.

This study shows that muscle-specific PolG dysfunction causes mitochondrial dysfunction and cachexia by activating the mtISR and altering the mitochondrial folate cycle.

This paper demonstrates that a standard 120-keV TEM with a direct electron detector can achieve high-resolution cryo-EM reconstructions of various proteins.

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

The paper identifies basal spot junctions in Drosophila epithelial tissues that respond to mechanical forces and regulate Hippo signaling by sequestering Warts kinase.

This study shows that blood glucose levels directly affect mitochondrial function and metabolism in early diabetic kidney disease, with changes in proteome, metabolome, and lipidome.

This study identifies biallelic HMGCS1 variants as a novel cause of rigid spine syndrome, showing hypomorphic effects through functional and clinical analyses.

This study elucidates how NanR represses sialic acid metabolism in E. coli by showing its cooperative DNA binding and allosteric regulation by N-acetylneuraminate.

The paper shows that mature myelin in adult mice is plastic and can modify node of Ranvier length and periaxonal space size to adjust action potential conduction velocity and synchronicity.

This study identifies Metformin as a potential therapy for BAG3 myofibrillar myopathy by rescuing muscle function in zebrafish models and reducing protein aggregates in human cells.

This paper determines the structure of MPEG-1, showing it forms a pre-pore complex and can perforate membranes under acidic conditions.