Michael B. Fessler

This study shows that DGKα and ζ deficiency in Tregs leads to their dysfunction, conversion to pathogenic Tfh cells, and triggers IgG1-predominant autoimmunity.

The paper identifies a transitional stage in breast cancer metastasis characterized by malignant epithelial diversification and inflammatory neutrophil remodeling, linking these to poor clinical outcomes.

TLR5 deficiency is linked to pulmonary fibrosis due to its role in preventing microbial dysbiosis following lung injury.

This study shows that Flotillin-2 reduces T cell sensitivity to weak antigen stimulation by regulating TCR clustering and signaling.

This study shows tissue-resident alveolar macrophages reduce O3-induced inflammation by clearing apoptotic cells via MerTK-mediated efferocytosis in mice and humans.