BiochemistrybioRxivPreprint
Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP
Matthew D. Callahan, Molly Hodul, Elizabeth C. Carroll…·Jason E. Gestwicki
This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.