Author

Matthew D. Callahan

University of California, San FranciscoORCID 0000-0002-1854-4212Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:proteomics· 1

Frequent Co-Authors

Cory M. NadeliD· 2 shared Jason E. GestwickiiD· 2 shared A. R. Cupo· 1 shared A.‐W. Kao· 1 shared Abby Oehler· 1 shared Anthony Ruvindi I. De SilvaiD· 1 shared Aye C. ThwiniD· 1 shared Charles S. CraikiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersBiochemistry

Cory M. NadelORCID

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2 papers

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedSep 12, 2024

Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP

Cory M. Nadel, Saugat Pokhrel, Kristin Wucherer…·Jason E. Gestwicki

This study identifies phosphorylation at residue S416 on tauC3 as a mechanism that inhibits its degradation by CHIP, contributing to its accumulation in Alzheimer's disease.

33 citationstop 4%

humanproteomics

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BiochemistrybioRxivPreprintJul 17, 2023

Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP

Matthew D. Callahan, Molly Hodul, Elizabeth C. Carroll…·Jason E. Gestwicki

This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.

1 citation

C. elegansexperimental assay

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