Stefan Walter

This study uses lysosomal proteomics and knockdowns to analyze the cargo spectra of GARP and EARP complexes, revealing their distinct roles in protein trafficking and their links to neurodegenerative disorders.

This study shows lipid droplets are the site of VLCFA activation by Fat1, with Fat1 targeting LDs via an amphipathic helix and using a hydrophobic cavity to access substrates.

This study shows Rho5 regulates yeast glucose signaling by affecting carbohydrate metabolism, cell wall, and mitochondrial composition, with a role upstream of Ras2 in cAMP-PKA signaling and inhibiting respiratory capacity.

This study determines the structure of the yeast ceramide synthase complex using cryo-EM, revealing its active state and inhibition mechanism by fumonisin B1.

The paper determines the cryo-EM structure of the SPT-Orm2 complex and shows Orm2 has higher inhibitory potential than Orm1, despite similar structures.

The paper solves the structure of the CORVET tethering complex using cryo-EM and explains its role in promoting endosome fusion through interactions with Rab5 and PI3P.

This study shows that serine uptake via Gnp1 is critical for maintaining sphingolipid homeostasis in yeast by linking serine import to sphingolipid biosynthesis.