Takayuki Kato

This study identifies LipL32 as a key structural protein in Leptospira interrogans that maintains cell-envelope integrity and stiffness, affecting pathogenicity.

This study investigates the structural dynamics of the human KOR-Gi signaling complex with G-protein-biased and balanced agonists, identifying key residues involved in signaling bias.

This study identifies five conformational states of Na+-NQR in Vibrio cholerae using mutants and inhibitors, revealing that 2Fe-2S reduction drives Na+ translocation through structural rearrangements.

The paper uses optogenetics and cryo-ET to visualize actin cytoskeleton dynamics during lamellipodia formation, revealing distinct structural phases and actin turnover mechanisms.

The paper presents a 3.2 Å resolution cryo-EM structure of a dimeric F1-like ATPase complex in Mycoplasma mobile, revealing its role in gliding motility through conserved rotary mechanisms.

The paper determines the structure of the Na+-driven stator PomAB from Vibrio using cryo-EM and reveals the sodium ion pathway, ion selectivity mechanism, and inhibition by phenamil.

The paper introduces cryoMDM, a method that estimates 3D atomic models from single cryoEM particle images by matching them to simulated structural models, revealing intermediate structures of the SARS-CoV-2 spike protein.

This study shows that certain SARS-CoV-2 antibodies enhance infection by cross-linking spike proteins, causing NTD-RBD domain decoupling without needing the Fc region.

This study reveals a pH-induced conformational switching mechanism in Betanodavirus protrusions that governs infectivity through dynamic structural changes.

The paper reveals how hibernating ribosomes inhibit RNase I activity to regulate rRNA degradation and biofilm formation in E. coli.

This study uses phase plate cryo-EM to reveal conformational diversity in therapeutic IgG, achieving sub-nanometer resolution of the Fab fragment.

The paper introduces an epoxidized graphene grid (EG-grid) that improves particle density and orientation in cryoEM, enabling high-resolution structural analysis with fewer micrographs.

The paper reports the structure of the LP ring of the bacterial flagellar motor using electron cryomicroscopy, revealing its 26-fold symmetry and intersubunit interactions.

This paper introduces DEFMap, a deep learning method that extracts dynamics information from cryo-EM maps, achieving results comparable to molecular dynamics simulations and experimental approaches.

This study demonstrates that a multi-purpose TEM with a side-entry cryo-holder can achieve high-resolution cryo-EM single particle analysis, as shown by a 3 Å resolution map of apoferritin.