Benzene metabolites increase vascular permeability by activating heat shock proteins and Rho GTPases
Igor N. Zelko, Ahtesham Hussain, Marina V. Malovichko…·Sanjay Srivastava
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University of LouisvilleORCID 0000-0002-8989-0438Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
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Igor N. Zelko, Ahtesham Hussain, Marina V. Malovichko…·Sanjay Srivastava
Md Sanaullah Sajib, Fatema Tuz Zahra, Μαργαρίτα Λάμπρου…·Constantinos Marios Mikelis
This study identifies endothelial RhoA activation as a key driver of tumor cell transendothelial migration and metastasis, showing it can be inhibited to reduce metastatic potential.
Bo Zhu, Krishan Gupta, Kui Cui…·Hong Chen
This study shows that targeting liver epsins reduces atherosclerosis by preventing PCSK9-mediated LDLR degradation and improving LDL-C clearance.
Hao Wu, Kui Cui, Bo Zhu…·Hong Chen
This study shows that targeting endothelial FOXO1 reduces IGF2 levels, improves β-cell function, and enhances wound healing in diabetes.