Stephan Werner

This study uses multimodal 3D imaging to show that lysosomes dissolve cholesterol crystals in macrophages, with cyclodextrin enhancing this process.

This paper shows that ergosterol mediates natamycin aggregation in yeast plasma membranes, which underlies its antifungal activity and can be enhanced by sphingolipid inhibitors.

The paper develops a deep learning method to quantify lipophagy in yeast using fluorescence and cryo-soft X-ray microscopy data.

This paper develops a semi-supervised deep learning pipeline for automated 3D segmentation of cryo-SXT tomograms, validated on mammalian cell ultrastructure and filopodia morphology.

This study uses fluorescence and X-ray microscopy to show NPC2 facilitates cholesterol export from endo-lysosomes, altering membrane trafficking and organelle structure.