Matteo Iannacone

This study shows that CXCR3 on transferred T cells enhances the effectiveness of combining adoptive T-cell therapy with viral-vector vaccines in solid tumors.

This study identifies CD4+ cytotoxic T cells in the bone marrow that enhance granulopoiesis in aged mice, contributing to age-related diseases and showing that CCR5 inhibition can mitigate these effects.

This study identifies perineurial cells as integrators of leptin and sympathetic outflow, showing their role in obesity protection through barrier function and beta 2 adrenergic receptor regulation.

This study identifies a lymphoid tissue chemokine checkpoint that regulates CD8+ T cell release from dendritic cells, preventing loss of effector function.

The paper identifies early endothelial activation at the blood-nerve barrier as a key feature of ALS, occurring before CNS vascular changes and motor neuron damage.

The paper shows that T cell-derived IFN-γ suppresses TFH differentiation and antibody responses by acting through dendritic cells, not directly on CD4+ T cells.

This study shows that inhibiting LSD1 enhances CD8+ T cell function in adoptive T cell therapy, leading to improved antitumor immunity and synergistic effects with anti-PDL1 therapy.