Andrew Jesse Connell

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

This study isolates and characterizes V2 apex-directed neutralizing antibodies from SHIV-infected macaques, revealing structural and genetic features that enable broad neutralization.

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study shows that germline-targeting SCIVs can activate and expand B cells expressing V2-apex bnAb-like precursors in rhesus macaques.

This paper develops a method to accurately determine SMN1 and SMN2 copy numbers from whole-genome sequencing data, enabling SMA diagnosis and carrier screening with high precision and recall.

Sunbeam is a modular pipeline for metagenomic analysis that standardizes preprocessing and removes low-complexity reads, enabling reproducible and extensible workflows.