Bette Korber

This study compares CD8+ T cell and antibody responses in non-human primates using different ratios of modified and unmodified mRNA-LNP vaccines with IL-12 boosting.

This paper develops updated HIV-1 pseudovirus panels to better detect and assess B cell lineages with potential to produce broadly neutralizing antibodies against contemporary HIV-1 variants.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This study designs a dual-epitope vaccine targeting HIV-1 Env's fusion peptide and V2 apex, showing it elicits neutralizing antibodies against both sites in rhesus macaques.

This study shows a novel two-step mechanism for inducing broadly neutralizing HIV antibodies in macaques using a modified SHIV, informing vaccine design.

This study shows that transient glycan deletions in SHIVs can induce CD4-binding site broadly neutralizing antibodies in macaques, offering a model for HIV vaccine design.

This paper presents a T-cell vaccine targeting conserved regions across Sarbecoviruses to provide cross-protection against evolving variants.

This study engineers an HIV broadly neutralizing antibody to improve its potency, antiviral activity, and manufacturability while maintaining safety and efficacy.

The paper identifies B cell priming as the main obstacle to developing HIV-1 V2 apex broadly neutralizing antibodies in SHIV-infected macaques.

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

This paper analyzes global SARS-CoV-2 variant transitions from 2020-2022, finding associations with vaccination rates, co-circulating variants, and natural immunity.

The paper identifies two lineages of Monkeypox virus in the U.S. in 2021-2022, finding a common ancestor and evidence of APOBEC3 editing in West African strains.

The paper uses network analysis of SARS-CoV-2 Spike protein variants to identify critical residues and assess the impact of mutations on protein function and adaptation.

The paper shows that recombination and low diversity reduce the sensitivity of homoplasy-based methods to detect increased transmissibility of the G614 SARS-CoV-2 variant.