Arturo Casadevall

This study identifies a soluble cell wall component in Lomentospora prolificans that reduces amphotericin B activity, differing from mechanisms in other fungi.

This study compares thermotolerance, UV-C tolerance, and biofilm formation in R. mucilaginosa strains from different origins on medical plastics.

This study investigates the role of Aqp1 in Cryptococcus neoformans cell morphology, finding that its loss leads to smaller cells while overexpression causes enlarged titan-like cells linked to redox physiology and oxidative stress.

This paper investigates how calcium triggers Cryptococcus neoformans aggregation through coordination bonds with glucuronoxylomannan, revealing its role in capsule structure and host interaction.

This study shows antigen stimulation can reactivate HIV-1 proviruses integrated in repressive chromatin, suggesting deeper latency may contribute to viral rebound.

This study shows Cryptococcus spp. exhibit stochastic capsule size dynamics, with a bet hedging strategy that balances stress resistance and growth rate.

The paper presents a generative AI pipeline for discovering antifungal peptides, identifying five with activity against fungal pathogens and low cytotoxicity.

This study identifies Itr4, a novel inositol transceptor in Cryptococcus neoformans, which regulates inositol and glucose metabolism and fungal virulence.

This study shows that mitochondrial homeostasis in Cryptococcus neoformans affects metabolic plasticity and virulence through the PKA pathway.

The paper introduces a heat-ramp method to study regulated cell death in Cryptococcus neoformans, revealing a protracted cell death process in pathogenic yeast.

This study isolates and characterizes cryptococcal phagosomes from different host cells, revealing conserved fungal responses and suggesting host metabolism as a target for survival.

The paper identifies fungal proliferation in North America before and after the Cretaceous-Paleogene extinction, linking it to climatic cooling and Deccan Traps activity.

This study compares laboratory and clinical assays for measuring cryptococcal polysaccharide, finding that structural variability among strains affects assay sensitivity and results.

The paper identifies mixed plates in a Cryptococcus neoformans knockout collection and proposes an authentication method to distinguish between different KO libraries.

This study shows dietary L-DOPA increases melanization, immunity, and reduces lifespan in Anopheles mosquitoes, while lowering malaria parasite burden.

This study identifies protective antibodies against Mycobacterium tuberculosis and shows that their Fc-effector function and Fab domains collaborate to restrict infection through immune cell reorganization.

This study uses timelapse imaging to analyze Cryptococcus neoformans infection dynamics in Galleria mellonella, revealing two distinct mortality phases and deterministic infection progression.

This study shows that peroxisomes in Cryptococcus neoformans regulate virulence and cell density sensing through metabolic pathways and mitochondrial retrograde signaling.

This study presents three chromosome-level genome assemblies of Lomentospora prolificans, revealing a chromosomal translocation event between strains.

This study characterizes melanin in Lomentospora prolificans, revealing multiple melanin types and suggesting a new type synthesized alongside DHN-, DOPA-, and pyomelanin.

This study examines how fungal extracellular vesicles mediate communication between fungal species and modulate immune responses, revealing their role in virulence and biofilm formation.

This paper investigates how salinity and polysaccharide rafts affect the buoyancy and persistence of Cryptococcus cells in water, with implications for their transport and pathogenic potential.

This study shows that melanin in Cryptococcus neoformans sequesters calcium, impairing polysaccharide capsule formation and leading to increased shed polysaccharide that may affect host immunity.

This paper examines the relationship between serotype, chemotype, and genotype in Cryptococcus spp., finding no strong correlation between these classifications and GXM motif expression, and introduces a new method for polysaccharide characterization.

This study shows that glutathione metabolism in Cryptococcus neoformans affects virulence by modulating redox processes and melanin production in a murine infection model.

This paper develops a food color-based colorimetric assay to measure laccase activity in Cryptococcus neoformans strains, finding it to be cost-effective, irreversible, and not requiring constant monitoring.

This paper presents two semi-synthetic glycoconjugate vaccines targeting Cryptococcus neoformans GXM, showing immunogenicity and cross-reactivity in mice.

This study identifies four proteins associated with cryptococcal exopolysaccharides that affect virulence, capsule integrity, and biofilm formation through mutant analysis and mass spectrometry.

This study analyzes how author order in equal contributor listings is determined and whether gender bias persists after a policy requiring explanations for order was implemented.

The paper estimates the size of biomedical research fields by counting unique authors in PubMed publications, finding significant variation in subfield sizes and potential correlations with workforce strength and public health burden.