Rafi Ahmed

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

This paper develops a mechanistic model showing that intermediate antibody levels and low CD8+ T-cell immunity increase dengue disease severity, and that CD8+ T-cell responses can mitigate antibody-dependent enhancement.

This study shows efineptakin alfa (NT-I7) improves survival and induces tertiary lymphoid structures in murine lung tumors, potentially enhancing immunotherapy efficacy.

This study shows that helpless CD8+ memory T cells, which form without CD4+ help, have transient functional impairments due to prolonged antigen exposure, which resolve over time.