Tae–Hoon Shin

This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.