Cynthia E. Dunbar

This study identifies an epigenetically distinct HSC subset, Kitlo, that supports better thymic and T-cell reconstitution in mice and humans.

The paper demonstrates a method to track ex vivo generated B cells in non-human primates using PET imaging, showing stable distribution and feasibility of repeated infusions.

This study compares CRISPR/HDR and lentiviral transduction effects on HSPC engraftment and clonal dynamics in rhesus macaques, finding HDR-edited cells decline rapidly while lentiviral cells persist longer.

This study investigates how clonal hematopoiesis affects COVID-19 severity and pathophysiology in rhesus macaques, finding prolonged inflammation and higher viral persistence in CH animals.

barcodetrackR provides tools for analyzing clonal tracking data to study lineage reconstitution and clonal dynamics in gene and cell therapy studies.

The paper validates off-target effects of CRISPR/Cas9 in rhesus macaques using error-corrected sequencing, showing that in vitro and in silico methods have limited predictive accuracy.

This paper reports a case of clonal hematopoiesis in a rhesus macaque following lentiviral transduction of HSPC with a strong retroviral promoter, leading to gene overexpression and aberrant splicing.