Author
Novo Nordisk FoundationORCID 0000-0002-9800-0409Unclaimed ORCID profile · follow to get notified of new preprints
Mutual co-authors in cluster
3 papers
Recent·Most cited
Deniz Durmusoglu, Daniel J. Haller, Ibrahim S. Al’Abri…·Nathan C. Crook
This study engineers S. boulardii to control gene expression and gut residence time via diet-responsive systems, enabling precise therapeutic delivery in the mouse gut.
Karl Alex Hedin, Vibeke Kruse, Ruben Vazquez-Uribe, Morten Otto Alexander Sommer
This paper develops a biocontainment strategy for Saccharomyces boulardii by knocking out THI6 and BTS1, resulting in auxotrophy and cold sensitivity, which limits its growth outside the host.
Karl Alex Hedin, Hongbin Zhang, Vibeke Kruse…·Morten Otto Alexander Sommer
This study engineers a probiotic yeast to produce a GLP-1R agonist in the gut, reducing obesity in mice through improved metabolism and weight loss.