Carlos P. Roca

The paper uses probabilistic modeling on a parabiosis dataset to analyze lymphocyte migration kinetics and dwell times across tissues, revealing cell type- and tissue-specific residency patterns.

This paper introduces Regulation Flow Analysis (RFA), a method that generates causal hypotheses of drug mechanisms using knowledge graphs, improving understanding of biological processes and drug development.

The paper analyzes tissue-resident regulatory T cells (Tregs) in non-lymphoid organs, showing they share phenotypes, transient residency, and TCR sequences, with tissue-agnostic re-entry capabilities.

AutoSpill calculates spillover coefficients for high-parameter flow cytometry data using automated gating and iterative refinement, improving compensation without requiring manual tuning or well-defined controls.