Author
University of North Carolina at Chapel HillORCID 0000-0003-0252-7140Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Joshua E. McGee, Jack R. Kirsch, Devin Kenney…·Mark W. Grinstaff
This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.
Bhawana Shrestha, Alison Schaefer, Elizabeth C. Chavez…·Samuel K. Lai
The paper designs tetravalent anti-sperm IgGs with enhanced agglutination potency compared to the parent IgG, while maintaining production yields and thermostability.
Bhawana Shrestha, Alison Schaefer, Jamal I. Saada…·Samuel K. Lai
The paper engineers multivalent IgG antibodies that agglutinate sperm more potently than monovalent IgGs, achieving high contraceptive efficacy in sheep.
Sara Adel Amin, Elizabeth C. Chavez, Vladimir O. Porokhin…·Soha Hassoun
The paper predicts new metabolites and reactions in E. coli using enzyme promiscuity and metabolomics data, enhancing the iML1515 metabolic model.