Author

Joshua E. McGee

Boston UniversityORCID 0000-0003-3327-6209Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Assay:multiome· 2 Assay:protein structure· 2 Research Focus:gene regulatory network inference· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Mark W. GrinstaffiD· 3 shared Wilson W. WongiD· 3 shared Kexin LiiD· 2 shared Colin PorteriD· 1 shared Dana C. ShawiD· 1 shared Devin KenneyiD· 1 shared Elijah Hammarlund· 1 shared Elizabeth C. ChaveziD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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3 shared papersBioengineering

Mark W. GrinstaffORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintApr 19, 2026

Single injection of modified self-amplifying RNA encoding a CD19 bispecific T cell engager mediates long-term malignant B cell clearance

Kexin Li, Joshua E. McGee, Wilson W. Wong, Mark W. Grinstaff

This study develops a modified self-amplifying RNA-based BiTE system that provides long-term B cell clearance with a single injection.

DOI 10.64898/2026.04.18.719371

mouseprotein structure

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NeurosciencebioRxivPreprintOct 30, 2025

Modified self-amplifying RNA mediates robust and prolonged gene expression in the mouse and ex vivo human brain

Jennifer Freire, Sicheng Pang, Joshua E. McGee…·Xue Han

This paper demonstrates that modified self-amplifying RNA (saRNA) enables long-lasting protein expression in mouse and human brain tissues.

1 citation

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BioengineeringNature BiotechnologyPeer-reviewedJul 8, 2024

Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA

Joshua E. McGee, Jack R. Kirsch, Devin Kenney…·Mark W. Grinstaff

This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.

111 citationstop 1%

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