Author

Jack R. Kirsch

Boston UniversityORCID 0000-0002-6808-7056Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:multiome· 1

Frequent Co-Authors

Mark W. GrinstaffiD· 2 shared Amanda K. WilliamsoniD· 1 shared Danny S. RohiD· 1 shared Devin KenneyiD· 1 shared Elizabeth C. ChaveziD· 1 shared Faith CerboiD· 1 shared Florian DouamiD· 1 shared Joshua E. McGeeiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersBioengineering

Mark W. GrinstaffORCID

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2 papers

Recent·Most cited

BioengineeringbioRxivPreprintDec 10, 2025

Relaxin-2 drives regenerative healing and suppresses scar formation

Amanda K. Williamson, Katherine Hohl, Jack R. Kirsch…·Mark W. Grinstaff

This study shows that relaxin-2 reduces fibrosis and promotes regenerative healing by inhibiting TGF-b1-driven ECM deposition in both in vitro and in vivo models.

DOI 10.64898/2025.12.08.692836

humanmouse

𝕏 PostBluesky

BioengineeringNature BiotechnologyPeer-reviewedJul 8, 2024

Complete substitution with modified nucleotides suppresses the early interferon response and increases the potency of self-amplifying RNA

Joshua E. McGee, Jack R. Kirsch, Devin Kenney…·Mark W. Grinstaff

This paper shows that complete substitution of nucleotides in self-amplifying RNA (saRNA) reduces interferon response and enhances expression, improving vaccine potency.

111 citationstop 1%

humanmouse

𝕏 PostBluesky