Author

Mark Manzano

University of Arkansas for Medical SciencesORCID 0000-0003-0284-7961Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:development & morphogenesis· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Aakaanksha MaddineniiD· 1 shared Ajinkya PatiliD· 1 shared Allison C. Farrar· 1 shared Alyssandra Navarro· 1 shared Andrew Murphy· 1 shared Daniel Dunham· 1 shared Darby G. OldenburgiD· 1 shared Debopam GhoshiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperMolecular Biology

Aakaanksha MaddineniORCID

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3 papers

Recent·Most cited

Cancer BiologyPLoS PathogensPeer-reviewedOct 1, 2026

The Mitochondrial Ubiquitin Ligase MARCHF5 Cooperates with MCL1 to Inhibit Apoptosis in KSHV-Transformed Primary Effusion Lymphoma Cell Lines

Prasanth Viswanathan, Justine R Bersonda, Jackson Gill…·Mark Manzano

This study identifies a genetic interaction between MCL1 and MARCHF5 in PEL cells, showing that MARCHF5 promotes cell survival by degrading NOXA, an antagonist of MCL1.

DOI 10.1371/journal.ppat.1014665

humanproteomics

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MicrobiologyNature CommunicationsPeer-reviewedJan 22, 2025

Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment

Shana M. Owens, Jeffrey M. Sifford, Gang� Li…·James Craig Forrest

This study shows that p53 activation restricts MHV68-driven GC B cell expansion during latency, with M2 and LMP1 triggering p53-dependent anti-proliferative responses.

6 citations

mouseexperimental assay

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Molecular BiologybioRxivPreprintSep 23, 2024

Cytotoxicity of Activator Expression in CRISPR-based Transcriptional Activation Systems

Aakaanksha Maddineni, Ziyan Liang, Shreya Jambardi…·Eva Gottwein

This study shows that CRISPRa systems can cause cytotoxicity, limiting their use in research and genetic screens.

3 citations

humanCRISPR screen

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