Benedetto Daniele Giaimo

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

The paper identifies genomic features associated with Notch responsiveness by analyzing RBPJ binding dynamics and develops a machine learning approach to predict Notch responsiveness in different cellular contexts.

This study shows that SPEN is essential for Xist upregulation during X chromosome inactivation initiation in female mouse ESCs by silencing Tsix.