J. Christof M. Gebhardt

The paper investigates the distinct roles of SRCAP and H2A.Z in gene regulation during the cell cycle in pluripotent stem cells, revealing SRCAP's H2A.Z-independent inhibitory function and H2A.Z's repressive role in lineage-specific gene expression.

The paper investigates cohesin and CTCF chromatin binding dynamics during zebrafish embryogenesis, showing increased binding efficiency and its role in chromatin architecture formation.

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

CaiNet simulates gene regulatory networks with stochastic molecular kinetics and infers steady-state network structure from measurements.

The paper shows that mitotic chromosome binding of transcription factors correlates with their interphase properties and impact on chromatin accessibility.