Author

Philipp Hoffmeister

University Hospital Ulm

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Biophysics· 1

Signature Assays, Organisms & Methods

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Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Organism:human· 1

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Benedetto Daniele GiaimoiD· 1 shared Duyen Huynh· 1 shared Francesca FerranteiD· 1 shared Franz OswaldiD· 1 shared J. Christof M. GebhardtiD· 1 shared Kefan ZhangiD· 1 shared Marek BartkuhniD· 1 shared Rhett A. KovalliD· 1 shared

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Benedetto Daniele GiaimoORCID

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1 paper

Recent·Most cited

BiophysicsNature CommunicationsPeer-reviewedFeb 1, 2025

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding

Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich…·J. Christof M. Gebhardt

The paper investigates RBPJ-DNA binding kinetics and cofactor interactions, finding that kinetic stability, not thermodynamic, governs target site specificity and that mutations affect both association and dissociation rates.

14 citations

humanChIP-seq

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