Yang C. Zeng

This study validates DoriVac, a DNA origami vaccine, as an effective treatment for metastatic melanoma in mouse models, showing reduced tumor nodules and enhanced immune activation when combined with PD-L1 blockade.

This study demonstrates that DNA origami vaccine nanoparticles enhance both humoral and cellular immune responses against infectious diseases like SARS-CoV-2, HIV, and Ebola.

The paper quantifies cargo on DNA origami nanoparticles using gel-based and fluorescence-based methods for therapeutic applications.