Tristan Tay

The paper develops an antigen-specific assay for T cell exhaustion and identifies IKAROS as a driver of exhaustion, showing that iberdomide prevents exhaustion by blocking chromatin remodeling.

The paper shows that the epigenetic state of the cell of origin influences susceptibility to Tet2 mutation, with Sox4 promoting dedifferentiation and increased clonal output in hematopoietic stem cells.

The paper introduces PRINT, a deep learning method to correct chromatin accessibility data and analyze DNA-protein interactions, revealing structural and functional changes in cis-regulatory elements during hematopoiesis and aging.

The paper introduces SHARE-seq, a method to profile RNA and chromatin in single cells, and identifies DORCs that predict lineage commitment by chromatin accessibility changes.