Nichlas M. Engels

The paper describes methodological advances at the LiX beamline for high-throughput muscle diffraction experiments on human and animal muscle tissues.

This study shows that different MyBP-C paralogs have similar effects on cross-bridge cycling but distinct responses to rapid stretch, with MyBP-C limiting strain-induced detachment in fast-twitch muscles.

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

This study shows that MyBP-CC1C7 domains form C-links and stabilize myosin OFF states, affecting crossbridge kinetics and sarcomere function.

The paper investigates how titin-based forces affect cardiac myofilament structures under stretch, supporting the Frank-Starling mechanism.