Timothy J. Nickels

This study identifies calcineurin signaling as a regulator of echinocandin tolerance and persistence in Candida glabrata and Candida albicans, suggesting potential therapeutic strategies.

This study uses Tn-seq to analyze genetic and epigenetic variation in Candida glabrata strains, revealing structural differences, resistance mechanisms, and subtelomeric chromatin accessibility.

This study identifies calcineurin-dependent genes and pathways critical for fitness in Candida glabrata under various stress conditions, highlighting roles in cell wall biosynthesis and vesicular trafficking.

This study identifies new genes and mechanisms regulating fluconazole resistance in C. glabrata, showing Pdr1 senses cellular stress rather than directly responding to antifungals.

The paper uses live-cell single particle imaging to show that RNA polymerase II and Kin28/Cdk7 kinase are required for H2A.Z eviction in yeast, linking it to transcription processes.