Kyle W. Cunningham

This study identifies gain-of-resistance mutations in FKS2 causing heteroresistance in Candida glabrata through heterogeneous gene expression, and shows regulators like calcineurin and IRA1 influence this phenomenon.

This study identifies calcineurin signaling as a regulator of echinocandin tolerance and persistence in Candida glabrata and Candida albicans, suggesting potential therapeutic strategies.

This study uses Tn-seq to analyze genetic and epigenetic variation in Candida glabrata strains, revealing structural differences, resistance mechanisms, and subtelomeric chromatin accessibility.

This study identifies calcineurin-dependent genes and pathways critical for fitness in Candida glabrata under various stress conditions, highlighting roles in cell wall biosynthesis and vesicular trafficking.

This study identifies new genes and mechanisms regulating fluconazole resistance in C. glabrata, showing Pdr1 senses cellular stress rather than directly responding to antifungals.

The paper identifies essential genes and fluconazole resistance genes in Candida glabrata using Hermes transposon insertion profiling and machine learning.

The paper compares transposon mutagenesis methods in yeast to infer gene essentiality, finding biases in insertion sites and recommending transposon choices for accurate essentiality prediction.