Steve Lacroix

The paper identifies a novel subset of IL-1R1+ nociceptors in mice using multimodal transcriptomics and calcium imaging, revealing their role in inflammatory pain.

This study shows that neurons internalize and clear immunoglobulins after CNS injury through lysosomal degradation, and inhibiting lysosomal proteases increases IgG retention without affecting locomotor recovery.

This study identifies Parkinson's disease risk genes expressed at brain barriers and shows poor transcript-protein correlation and low interspecies conservation.

This study shows that MOG-specific B cells worsen CD4+ T cell-driven CNS autoimmunity by promoting Th17 and Tph cell accumulation via IL-23.