Leïla Perié

This study identifies the pentose phosphate pathway's role in regulating myeloid versus lymphoid lineage specification in hematopoietic stem and progenitor cells through metabolic state-fate mapping.

The paper shows that IFNg induces both stemness and differentiation in AML cells, leading to heterogeneous responses that affect leukemia growth and regeneration.

The paper shows clonal memory in human HSPCs persists across divisions and is disrupted in AML, with potential for therapeutic modulation.

The paper introduces OneCell CUT&Tag, a single-cell multi-omics method that captures chromatin, transcriptome, and surface marker data, revealing epigenomic reprogramming during mammary gland basal-to-luminal transition.

The paper uses genetic barcoding and single-cell transcriptomics to identify evolutionary trajectories in breast cancer cells, linking them to poor patient survival.

The paper identifies a common origin for effector and regulatory CD4+ T cells in non-small cell lung cancer through single-cell analysis, revealing their plasticity and role in immune responses.

This study characterizes a humanized in vivo bone marrow model, hOss, showing its impact on human hematopoietic development and clonal interactions.

This study shows NK cells influence all phases of cancer immunoediting in B-ALL, promoting resistant clones through selective pressure and identifying LY6E as a marker of poor prognosis.

scMitoMut is an R package that improves mitochondrial mutation calling in single cells by using statistical methods, showing better sensitivity and precision than existing tools.

The paper identifies CXCL8 secreted by immature granulocytes as a factor inhibiting wildtype hematopoiesis in CMML, suggesting CXCL8 blockade could slow disease progression.

The paper introduces DivisionCounter, a method to count large cell divisions in vivo, showing leukemia tumor division rates are independent of microenvironment and CAR-T treatment.

This study tracks division and differentiation of hematopoietic stem and progenitor cells to show that cells from the same ancestor are homogeneous despite population-level heterogeneity.