Tim Rasmussen

The paper presents the high-resolution structure of Escherichia coli MscL in nanodiscs, revealing a pentameric assembly and a previously unreported dimeric association.

This study identifies SLC26A11 as a dual-function protein that acts as both a sulfate transporter and a chloride channel, with implications for treating brain edema and lysosomal storage diseases.

The paper determines the structure of a filamentous NONO/SFPQ heterooligomer using cryo-EM, revealing its organization and functional differences between the components.

The paper investigates the structural gating mechanisms of YnaI, showing it opens via radial relocation of sensor paddles and pore shortening, contrasting with MscS's tilt-based mechanism.

This paper determines the structure of lymphostatin, a multifunctional virulence factor in E. coli, revealing its domains and mechanism of action.

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.