Fabrice E. Graf

This study compares laboratory evolution of piperacillin-tazobactam resistance in Klebsiella grimontii with within-patient resistance evolution, showing that small population bottlenecks reproduce key resistance mechanisms observed in clinical isolates.

The paper identifies novel β-lactamase genes from environmental Pseudomonas spp. isolates, showing their resistance properties and potential clinical relevance.

This study compares cefiderocol susceptibility testing methods against genomic resistance determinants in blaNDM-producing Enterobacterales, finding discrepancies between EUCAST and CLSI breakpoints and poor method agreement.

This study evaluates screening methods to detect ESBL-producing E. coli and K. pneumoniae in healthcare environmental samples, finding that 18-hour pre-enrichment and specific selective agar improve detection.

The paper investigates the re-emerging chloramphenicol susceptibility in ESBL-producing Enterobacterales by analyzing genotype-phenotype discordance and molecular mechanisms.

This study shows that β-lactamase expression in E. coli induces collateral sensitivity to colistin and azithromycin, suggesting a therapeutic strategy to counter mobile AMR.