Author

Chintan K. Kikani

University of KentuckyORCID 0000-0003-1140-0192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:deep learning· 2 Research Focus:development & morphogenesis· 2 Research Focus:protein folding & dynamics· 2

Frequent Co-Authors

Sajina DhungeliD· 4 shared Rajaian Pushpabai RajeshiD· 3 shared Michael J. XiaoiD· 2 shared Aanya Parasramka· 1 shared Aarush Kikani· 1 shared Brian Kelly· 1 shared Chia-Hua WuiD· 1 shared David Sabatini· 1 shared

Activity by Year

2017-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersBiochemistry

Sajina DhungelORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cell BiologybioRxivPreprintMar 27, 2026

A Deep-Learning Atlas of XPO1-Mediated Nuclear Export at Proteome Scale

Sajina Dhungel, Sihara de Zoysa, DeAnna Burns…·Chintan K. Kikani

The paper uses deep learning to create an atlas of XPO1-mediated nuclear export, identifying thousands of new NESs and revealing structural patterns and regulatory mechanisms.

DOI 10.64898/2026.03.25.713363

humanproteomics

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BiochemistrybioRxivPreprintOct 2, 2025

Glutamine-Dependent Slc25a39-Nrf2 Axis Couples Mitochondrial Dynamics with Metabolic Reprogramming to Establish Myogenic Commitment

Brian Kelly, Chia-Hua Wu, Kaan Ihsan Eskut…·Chintan K. Kikani

DOI 10.1101/2025.10.02.680066

mousebulk RNA-seq

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BiochemistryProceedings of the National Academy of SciencesPeer-reviewedMar 19, 2025

Nutrient Signaling-Dependent Quaternary Structure Remodeling Drives the Catalytic Activation of metazoan PASK

Sajina Dhungel, Michael J. Xiao, Rajaian Pushpabai Rajesh, Chintan K. Kikani

This study identifies a nutrient-responsive quaternary structure remodeling in metazoan PASK through structural and evolutionary analysis, linking nutrient sensing to catalytic activation.

3 citations

humanmouse

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BiochemistryJournal of Molecular BiologyPeer-reviewedSep 6, 2023

Signal-regulated unmasking of the nuclear localization motif in the PAS domain regulates the nuclear translocation of PASK.

Michael J. Xiao, Sajina Dhungel, Roksana Azad…·Chintan K. Kikani

This study identifies a mechanism by which PASK's nuclear translocation is regulated by the interaction between its PAS-A domain and a PIM motif, which is modulated by metabolic signals.

2 citations

humanproteomics

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Cell BiologybioRxivPreprintDec 10, 2017

mTORC1 activates PASK-Wdr5 signaling to epigenetically connect the nutrient status with myogenesis.

Chintan K. Kikani, Xiaoying Wu, Sarah Fogarty…·Jared Rutter

The paper shows mTORC1 activates PASK-Wdr5 signaling to epigenetically link nutrient status with myogenesis by promoting Myogenin transcription and differentiation.

DOI 10.1101/232173

mouseproteomics

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