Saber H. Saber

This study designs and validates protease-resistant antiviral peptides that inhibit SARS-CoV-2 fusion, showing improved efficacy in vitro and in vivo.

This study shows SARS-CoV-2 infects hiPSC-derived neurons via endosomal-lysosomal pathway dependent on cathepsins, leading to HIF1alpha accumulation and phosphorylated tau, suggesting neurodegenerative effects.

The paper shows that DDHD2-generated saturated fatty acids are essential for neuronal energy production and synaptic function.

This study shows that transmitted alpha-synuclein extracellular vesicles reduce retrograde axonal transport in recipient neurons, with effects dependent on endogenous alpha-synuclein interaction.

This study shows that combining PIKfyve and TMPRSS2 inhibitors intranasally protects mice from SARS-CoV-2 lung infection and reduces cell death.

This paper shows that botulinum neurotoxin type A (BoNT/A) toxicity relies on synaptotagmin 1 (Syt1), which forms nanoclusters with PSG and SV2 on neuronal membranes, enabling endocytic targeting and neuronal communication disruption.

This study shows that DDHD2 and STXBP1 interact to generate myristic acid, which is essential for long-term memory formation in mice.