Huixian Wu

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

Omicron JN.1- and KP.2-adapted BNT162b2 mRNA vaccines elicit stronger neutralizing antibody responses against circulating sublineages than previous vaccines, supporting annual strain updates.

The paper designs a conformationally stabilized FimH antigen for a UTI vaccine, showing improved immunogenicity and structural similarity to native FimH.

The monovalent Omicron XBB.1.5-adapted BNT162b2 mRNA vaccine elicits stronger neutralizing antibody responses against XBB.1.5 and related sublineages than the bivalent Wild Type + Omicron BA.4/5 vaccine.

This paper presents two inactive CCR6 structures bound to allosteric antagonists, revealing structural insights into CCR6 inhibition and its implications for drug discovery.

This study identifies potent SARS-CoV-2 PLpro inhibitors using machine learning, showing efficacy in a mouse model of COVID-19.