Joshua M. Toth

The paper develops a model linking matrix stiffness and ligand density to cellular bioenergetics in cancer cells, showing how mechanical forces influence metabolic pathways and contractility.

The paper develops a polymer model integrating super-resolution imaging and epigenomic sequencing to show how epigenetic reactions shape 4D chromatin organization and influence gene expression and metastatic potential.

This study identifies CD44 as a key mediator of cell traction force generation in hyaluronic acid-rich extracellular matrices, showing its role in modulating collagen network mechanics and tumor invasion.