Edna C. Hardeman

This paper introduces iSiMM, a method for tracking single molecules in live tissues, and demonstrates its application to study protein dynamics in mice.

This study shows Tpm1 promotes platelet adhesion and clot contraction independently of its role in embryonic hematopoiesis, linking it to thrombotic disease risk.

This study shows PIEZO1 supports apoptotic cell extrusion by maintaining mechanical homeostasis rather than through calcium signaling.

This study investigates the role of Tpm4.2 in neuronal processes by analyzing knock-out mice, finding altered signaling, neurite outgrowth, and sex-dependent behavioral phenotypes.

The paper identifies a selective JNK inhibitor that blocks metastasis in triple-negative breast cancer by targeting metabolic pathways.

The paper shows how actin filaments dynamically adjust their structure to control membrane transfer between cellular compartments in live rodents.

This study shows that an APC truncation mutant increases epithelial tissue tension via RhoA/ROCK, impairing apical cell extrusion and potentially contributing to disease.

This study shows that pre-existing mechanical tension at adherens junctions impairs apoptotic extrusion in epithelia, and this effect can be reversed by reducing tension.

This study identifies Tpm3.1 as essential for maintaining AIS structure and function by stabilizing actin filaments in the axon initial segment.