Matthew R. Markovetz

This study identifies airway epithelial host defense defects caused by STAT3 mutations in Hyper IgE Syndrome, contributing to chronic pulmonary infection.

The paper measures cervical mucus viscoelasticity and sperm velocity in rhesus macaques, finding a strong negative correlation between mucus viscoelasticity and sperm velocity.

Inhibiting CFTR in endocervical cells leads to dehydrated, thickened mucus production in vitro.

This paper develops statistical methods to analyze rheological heterogeneity in CF-related airway mucus using particle-tracking and noise decomposition.

This study investigates how C. difficile uses host-derived mucus for growth, metabolism, and biofilm formation, revealing metabolic shifts and potential pathogenic mechanisms.

This study shows that increased mucin and eDNA concentrations in mucus enhance Pseudomonas aeruginosa antibiotic tolerance, and establishes an in vitro model to replicate this tolerance observed in sputum.

This paper tests combination treatments to disrupt Pseudomonas aeruginosa biofilms in mucus, finding that NP40, hyaluronic acid, and tobramycin most effectively increase mucociliary transport and reduce bacterial viability.