David Aaron Jacobson

This study identifies glutaminase as critical for α cell mass and glucagon secretion by linking glutamine metabolism to amino acid sensing and growth.

This study investigates how calorie restriction modulates beta cell Ca2+ homeostasis and network connectivity, finding that CR beta cells exhibit faster, shorter Ca2+ oscillations and reduced network connectivity.

This study shows MYT1 and ST18 regulate human beta-cell survival and insulin secretion under normal and stress conditions, with their genes enriched for T2D-risk loci.

This study shows Atf4 protects beta-cell function under high glucose but worsens beta-cell failure when combined with free fatty acids.

This study identifies purinergic Ca2+ signaling via P2X7 receptors as a mechanism enabling drug tolerance in BRAF-mutant melanoma, with implications for overcoming treatment resistance.

This study identifies miR-125b-5p as a glucose-regulated miRNA that negatively regulates β-cell function by modulating organelle dynamics and insulin secretion.

This paper identifies a MAFA S64F variant causing sex-dependent β cell dysfunction and diabetes by accelerating aging and senescence in males.

This study investigates the role of C2cd4b in murine glucose homeostasis, revealing sexually dimorphic effects on body weight and glucose tolerance.

This paper identifies TRPM7's critical role in pancreatic progenitor expansion and β-cell proliferation under insulin-resistant conditions through genetic studies in mice.

This study identifies a novel interaction between Shank3 and CaMKIIα that is essential for calcium channel signaling to the nucleus and gene expression changes during learning.

The paper identifies a novel gain-of-function mutation in KCNK16 causing MODY by impairing Ca2+ influx and glucose-stimulated insulin secretion.