Wei Wei

This study identifies MCT6 as an intestinal exporter of Lac-Phe, showing its role in metformin-induced weight loss and systemic metabolite regulation.

The paper identifies a conserved postprandial metabolite, pTOS, that links nutrient intake to energy balance through a gut-brain pathway in pythons and mice, with potential relevance to humans.

This study identifies a PTER inhibitor that reduces food intake and body weight in mice, linking PTER function to obesity treatment.

The paper identifies genes regulating mitochondrial fission in C. elegans and shows that chromosome missegregation leads to mitochondrial fission dysregulation, independent of Drp-1.

This study identifies a secondary BHB metabolic pathway mediated by CNDP2, leading to BHB-amino acid metabolites that regulate energy balance in mice and humans.

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

This study maps the organism-wide secretome response to exercise in mice, identifying 200+ exercise-regulated protein pairs and uncovering anti-obesity and anti-diabetic roles of a liver-secreted proteoform.

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.